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Advanced Depression Treatment
If your depression doesn't respond to a first-line antidepressant, your doctor might suggest increasing the dose or adding a different medication. They may also recommend psychotherapy.
Newer psychotherapy methods like augmented depression therapy offer empirical evidence-based support and can help reduce depression symptoms. These therapies are focused on identifying and resolving specific ways in which depression affects your daily life.
Transcranial magnetic stimulation (TMS)
TMS is a noninvasive brain stimulation technique that utilizes magnetic pulses to affect neurons that are responsible for mood. It is frequently suggested to treat depression when medications fail or are not suitable for the individual. It can also be used to treat PTSD and is sometimes combined with psychotherapy. TMS is an effective and safe treatment with no significant side adverse effects.
During the session, the healthcare professional will position an electromagnetic coil on your scalp that is over the region of the brain that regulates mood. In the case of rTMS, it is the dorsolateral prefrontal cortex (dLPFC). This is a small region located at the front of your brain. You will hear a click sound and feel a tapping sensation as the device delivers the brain with electrical impulses. The healthcare professional will adjust settings to stimulate the desired areas of the brain.
The healthcare professional will determine the strength of the pulses using the amount of energy required to trigger a thumb twitch. This is important as it allows them to determine how much power they're using and ensures the safety of the patient. In the past, the pulses were delivered at 120 percent of the threshold of motor. However, the current research is focused on accelerating TMS therapy to reduce time required to treat and improve the rate of response.
In a controlled, randomized study researchers have proven that TMS can help people with major depressive disorder (MDD) who do not respond to antidepressants. The study showed that those treated with rTMS saw significant improvement in symptoms like low mood, sadness, changes in appetite, and decreased enjoyment or interest in certain activities. The study also found that the improvements were long-lasting.
Contrary to other types of brain stimulation like vagus nerve stimulation or electroconvulsive therapy, TMS does not interfere with psychotherapy. It is safe for women who are pregnant and has a low risk of seizure. However, some people can feel pain or discomfort on the scalp underneath the magnet while they are receiving treatment.
The majority of TMS treatments last around half an hour. Your provider will tell you the length of time the treatment will be and may also stop the pulses at this point to let the magnet cool down.
Vagus nerve stimulation (VNS)
VNS (also called Vagus Nerve Stimulation) is an approach that utilizes controlled electrical signals that are timed to change brainwave patterns and reduce depression symptoms. The device is surgically implanted, and it uses tiny generators that are connected to a wire that is wound around the left Vagus nerve at the neck. The procedure has been approved by the FDA for treating depression that is resistant to treatment in patients who haven't found relief from other treatments such as psychotherapy or medication. It's also approved to control seizures in certain epileptic patients.
In the most comprehensive clinical study of VNS researchers compared the effectiveness with a sham device in people who had treatment-resistant monopolar or depressed-phase bipolar disorder. Patients in the VNS group received a low, medium or high dose of electrical stimulation during an 22-week "acute phase." The primary goal was improvement in the Inventory of Depressive Symptomatology (IDS-SR30). Patients in the VNS group had significantly better results than those in the sham group. At the 12-month check-up, the VNS group had an average IDSSR30 of 9.3 while the group of sham scored 4.2.
The VNS treatment was well-tolerated with the most common adverse effects being voice distortion or hoarseness as well as a feeling of weight on the chest. Other reported side effects were headache, tingling fatigue, fatigue and changes in swallowing or speech. Some of these occurred more frequently in higher dose groups, while others occurred at all doses. The rate of AEs was similar to that in other studies, and they were typically cleared by the end the acute study period.
Psychiatrists from Ohio State Wexner Medical Center are regularly invited to take part in national discussions on the best method to treat mood disorders and depression. Our experts are involved in shaping the national standards of care and are currently a participant for the Centers for Medicare and Medicaid Services RECOVER multicenter clinical trial to further evaluate VNS as a treatment for treatment-resistant depression. This is a significant research effort, as the evidence available suggests that VNS may provide improved benefits and hope to this difficult-to-treat chronic population.
Electroconvulsive therapy (ECT)
ECT is a powerful treatment for depression that doesn't improve with medication. It is particularly helpful for those who are suicidal, or are unable to wait until their medication to take effect.
During ECT doctors transmit small electrical currents to the head to trigger a short seizure. The result is that the brain changes chemistry, and improve symptoms of certain mental health issues. ECT has been used since the 1930s, and despite the stigma associated with the treatment, many people have successfully benefited from it.
To be given ECT your doctor will require an extensive psychiatric evaluation. Then they will examine your medical history and do a series of tests that include an electrocardiogram (EKG) and blood tests, and perhaps an X-ray of your chest. They will ask you to describe how you are feeling about ECT and consider any opinions of family members, friends, or advocates who are speaking on your behalf.
The ECT procedure is performed under general anesthesia. This means that you will not feel any sensation. A mouth guard is put on to protect your teeth, and the mask is placed over your face for oxygen. An anesthesiologist injects an Anesthetic using a needle in your vein. Once you've fallen asleep, electrodes are placed on one or both sides of your head (depending on whether you have bilateral or unilateral ECT). They send small electrical impulses to the brain which cause a short seizure. It lasts for 20 to 60 seconds, and you'll be able to get up shortly after.
It is important to remember that you are able to revoke your consent to ECT at any time, even just before the first treatment. You have the right to withdraw your consent under Care Quality Commission (CQC) and your doctor should always take your preferences into consideration when deciding whether or not to make use of ECT.
ECT can be a beneficial treatment option for people who tried other treatments but failed to notice any improvement. It can also help those suffering from mild depression, severe psychosis, or when you're a risk to others or yourself and cannot wait for medication effects to take effect. In the majority of instances, you'll have to have several ECT sessions spread over three to six weeks.
Light therapy
Light therapy helps to compensate for the absence of sunlight, which may contribute to major depressive disorder with seasonal patterns (formerly known as seasonal affective disorder). It can be used as a separate treatment or to complement other treatments such as psychotherapy and medications. During light treatment you sit in front of a light box that emits white light that is bright and bright. The light is usually between 2,500 and 10,000 lux. Each session, you'll be sitting for 30 minutes at the lamp. The light can boost your mood and ease symptoms of SAD such as being tired all the time and sleeping excessively.
Researchers aren't aware of how light therapy can treat SAD. However, they are aware that it can have an impact on the circadian rhythms. Circadian rhythms are biological cycles that impact sleep patterns hormone levels, sleep patterns, and other vital functions. Light therapy can reset your internal clock by altering the release of melatonin, an ingredient that regulates the sleep-wake cycle. It can also affect neurotransmitter functions by affecting production of serotonin.
depression and anxiety treatment of studies have proven that light therapy can reduce depression symptoms and boost the effectiveness of antidepressant drugs. Additionally, some studies have shown that light therapy is effective in treating bipolar disorder. These results are encouraging and suggest light therapy may be a possibility for people who suffer from bipolar and depression disorder.
Before you start using light therapy, consult your doctor or mental health professional about it. They can help you choose the appropriate device for your needs and provide instructions on how to use it. They can also tell you whether it interacts with other medications that you are taking.
Light therapy is a safe treatment that doesn't cause serious adverse side negative effects. You should only use it when your doctor prescribes. If you're experiencing severe depression, it is crucial to seek treatment as soon as you notice it. Depression is a serious condition that can have serious effects on your mental and physical well-being. In extreme cases, depression can result in suicidal ideas. Seek immediate assistance from a mental health professional If you are experiencing suicidal thoughts.